Iran’s supreme leader criticized an initial proposal from the United States in negotiations over Tehran’s nuclear program.

Iran’s supreme leader, Ayatollah Ali Khamenei, said on Wednesday that abandoning uranium enrichment was “100 percent” against Tehran’s interests, effectively rejecting a key U.S. demand in weeks of tense negotiations over Iran’s nuclear program.

Iran's stance directly clashes with U.S. President Donald Trump 's position that Iran must halt all enrichment amid negotiations marked by uncertainty, despite having reached their most significant step since they began in April with a U.S. offer being delivered to Tehran last week.