The San Francisco 49ers are a prime candidate to go from worst to first in the division thanks to a favorable schedule in 2025.

The 49ers are 18-16 under the lights under Shanahan. They went 3-3 in prime-time games last season, losing their final three vs. the Bills, the Rams and the Lions. In his previous years, they were 0-1 in 2017, 1-2 in ’18, 5-1 in ’19, 1-3 in 2020, 1-3 in ’21, 4-1 in ’22, and 3-2 in ’23.

We're all winners with that elite Week 1 prime-time slate. But the Browns and Saints are schedule-release losers with no prime-time games.

The Giants, despite having a last-place schedule after finishing at the bottom of the NFC East, have the NFL’s hardest schedule for 2025 based on the team’s 2024 winning percentage of .547, according to Yahoo. The 49ers, who finished last in the NFC West, have the league’s easiest 17-game slate with a .415 opposing winning percentage.

Iyer picked the top game for all 32 teams' 2025 schedule and wrote that the Rams' matchups against the Detroit Lions in Week 15, the San Francisco 49ers in Weeks 5 and 10, and Atlanta Falcons in Week 17 will be those respective club's best games of their individual seasons.

De'Vondre Campbell infamously refused to enter the San Francisco 49ers' Week 15 game last season and that mistake may be costing him his future in the NFL.

The NFL is revealing the 2025 schedule for all 32 teams on Wednesday at 5:00 p.m. P.T., but there are always leaks ahead of time that creates a nice big puzzle. For the San Francisco 49ers, their first piece of the puzzle could be solved,

Mykel Williams plays a premium position -- defensive end. He's built like a young Aldon Smith. He's only 20. He's an elite run defender. And as a run defender, he'll get lots of one-on-one matchups playing opposite Nick Bosa.