Weighing the pros and cons of hot-melt extrusion and spray drying. The oral route remains the most preferred method for delivering drugs. It offers good patient compliance due to its acceptability, ...

Spray-drying is a preferred process for manufacturing amorphous solid dispersions, which provide oral bioavailability enhancement for low-solubility small molecules. High permeability, low-solubility ...

Raman imaging and scanning electron microscopy (SEM) was used to investigate acetaminophen solid dispersions prepared by hot melt extrusion (HME). This experiment confirmed that a high screw speed ...

Machine-learning approaches are being developed to produce accurate simulations of the structure and chemical bonding of disordered solids and liquids, modelling a sufficient number of atoms to enable ...

In industrial production, the surface of the compound may become amorphous due to a small amount of structural damage. It is difficult for conventional instruments to detect this small amount of ...