The amyloid-β precursor protein (APP) helps to form links between the brain’s neurons. It has been highly studied because its ...

The brain of a US woman with Down syndrome showed the classic signs of Alzheimer’s disease upon her death, yet she remained ...

We showed that conversion of Aβ to the fibrillar form markedly increased binding to specific neuronal membrane proteins, including amyloid precursor protein (APP). Nanomolar concentrations of ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

Gamma-secretase acts like a pair of molecular scissors, trimming a larger protein, called amyloid precursor protein, into smaller pieces, one of which is amyloid beta. Previous work by the ...

Scientists have identified a biomarker for Alzheimer's that may help doctors spot the early signs of protein buildup in the brain before it causes significant damage.

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. The research, published today in eLife, is described by editors as a fundamental study ...

DIAD results from highly penetrant mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1), or PSEN2, which lead to abnormal amyloid-β processing and early-onset Alzheimer's disease.

Researchers found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid formation by hen egg white lysozyme, a-synuclein, amyloid b 1-40, and b2-microglobulin. The high ...

These genes play critical roles in amyloid precursor protein (APP) processing and amyloid-β pathology and, alongside family history, can predict AAO with high accuracy. The Dominantly Inherited ...

Two main protein structures are associated with Alzheimer’s disease: amyloid-beta plaques and neurofibrillary tangles (NFTs). Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor ...