Increasing focus is now being placed on the production of Aβ—a process called proteolysis, during which a precursor protein ...

Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed ...

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain. A protein from Helicobacter pylori inhibits amyloid formation in both ...

Amyloid precursor protein, which generates amyloid-β when broken down, has long been associated with Alzheimer’s disease. But its normal function in the brain has remained relatively mysterious. Over ...

Explore the link between α2,6-sialyltransferase-I and Alzheimer's disease progression. Understand the new findings on ...

For this, they examined the expression of the genes BACE1 and APP, which code for beta-secretase component 1 and amyloid precursor protein, respectively, and the MBP gene, which codes for myelin ...

Pretty much everyone believes that amyloid has some link to Alzheimer’s—mutations in genes like presenilin and amyloid precursor protein, which play major roles in the generation and ...

Here, Tian et al. report that lactylation curbs Aβ production and plaque formation via lactate modification of specific lysines on amyloid precursor protein. This alters APP intracellular transport ...

Scientists at the USC Leonard Davis School of Gerontology have discovered a key connection between high levels of iron in the ...

Justyna Dobrowolska Zakaria Northwestern University, Feinberg School of Medicine; Posted: 01 Jul 2024 This report provides exciting new insights into the potential physiological role of a proteolytic ...

“The same Saps that the fungus uses to break the blood-brain barrier also break down the amyloid precursor protein into Ab-like peptides,” Wu said. “These peptides activate microglial brain cells via ...