This iron buildup is harmful because it triggers oxidative stress, a process that damages cells by producing toxic molecules.

Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed ...

Amyloid precursor protein, which generates amyloid-β when broken down, has long been associated with Alzheimer’s disease. But its normal function in the brain has remained relatively mysterious. Over ...

Increasing focus is now being placed on the production of Aβ—a process called proteolysis, during which a precursor protein ...

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain. A protein from Helicobacter pylori inhibits amyloid formation in both ...

Explore the link between α2,6-sialyltransferase-I and Alzheimer's disease progression. Understand the new findings on ...

For this, they examined the expression of the genes BACE1 and APP, which code for beta-secretase component 1 and amyloid precursor protein, respectively, and the MBP gene, which codes for myelin ...

Pretty much everyone believes that amyloid has some link to Alzheimer’s—mutations in genes like presenilin and amyloid precursor protein, which play major roles in the generation and ...

Here, Tian et al. report that lactylation curbs Aβ production and plaque formation via lactate modification of specific lysines on amyloid precursor protein. This alters APP intracellular transport ...

Justyna Dobrowolska Zakaria Northwestern University, Feinberg School of Medicine; Posted: 01 Jul 2024 This report provides exciting new insights into the potential physiological role of a proteolytic ...

When you look at the brain of someone with Alzheimer’s under a microscope, it requires two proteins — beta-amyloid and tau protein, which is thought to occur after amyloid, says Dr. Younes.