When we think of the immune system, most people imagine white blood cells putting up a fight against invading germs within ...

Study shows how cells employ a universal strategy, reliant on TRIM21, to redirect its autophagy machinery to any harmful material tagged with antibodies.

The body has an intricate system to defend against infections where each type of immune cell plays a distinct role. Now, a study led by researchers from the Penn State College of Medicine has ...

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

Antibodies—proteins that are produced by our immune system to protect us—are crucial for recognizing and getting rid of unwanted substances, or antigens, in our body. Although their role is universal, ...

An international research team has identified a previously overlooked factor that influences how antibodies neutralize SARS-CoV-2: their mechanical stability under force. Antibodies are key components ...

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...

Monoclonal antibodies target specific disease molecules. They can help treat cancer, autoimmune disorders, and infectious diseases. Discover what you should know about this therapy. Monoclonal ...

b) an Fc domain comprising amino acid substitutions M428L/N434S as compared to a human Fc polypeptide, wherein numbering is according to the EU index of Kabat, wherein said anti-C5 antibody with said ...

In the aftermath of those cases, some practitioners have suggested means-plus-function claiming as one strategy to obtain antibody claims that are broader in scope than the specific antibodies ...