The cause of Huntington's disease was discovered over three decades ago -- a "genetic stutter" mutation involves repeats of three letters of the DNA, cytosine-adenine-guanine (CAG), in a gene ...

HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease. George Huntington (Figure 1 ... precisely determine the number of CAG repeats present in the HTT gene ...

At birth, people who carry a string of more than 40 CAG repeats within the first exon of the huntingtin gene are all but destined to develop Huntington’s disease. Yet, recent studies are converging on ...

This promising strategy could slow or halt Huntington's disease progression at the root of its genetic cause. "Targeting MSH3 is exciting not only because it's directly involved in the CAG repeat ...

The pathogenic connection between huntingtin the protein and Huntington's the disease has eluded neurologists since 1993. 1 Researchers discovered then that a wild-type huntingtin gene had 35 or fewer ...

Lead author, Professor Sarah Tabrizi (UCL Huntington’s Disease Research Centre and UK Dementia Research Institute at UCL), said: “Our study underpins the importance of somatic CAG repeat expansion ...

Huntington’s disease stems from a mutation in the HTT gene, which includes a repetitive sequence of DNA known as the CAG repeat. While healthy individuals have between 15 and 35 CAG repeats ...

Huntington's disease kills a population of cells called ... Seeking to understand the direct biological effects of CAG-repeat length, the researchers adapted single-cell RNA-sequencing to help ...

Skyhawk presents today on its novel SKY-0515 small molecule RNA splicing modulator targeting Huntington's Disease to members ...

HDBuzz reported live updates on Bluesky from the 2025 HD Therapeutics Conference. Read on for coverage of Day 2. #CHDI2025 ...