The cause of Huntington's disease was discovered over three decades ago--a "genetic stutter" mutation involves repeats of three letters of the DNA, cytosine-adenine-guanine (CAG), in a gene called ...

At birth, people who carry a string of more than 40 CAG repeats within the first exon of the huntingtin gene are all but destined to develop Huntington’s disease. Yet, recent studies are converging on ...

HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease. George Huntington (Figure 1 ... precisely determine the number of CAG repeats present in the HTT gene ...

This promising strategy could slow or halt Huntington's disease progression at the root of its genetic cause. "Targeting MSH3 is exciting not only because it's directly involved in the CAG repeat ...

Huntington's disease kills a population of cells called ... Seeking to understand the direct biological effects of CAG-repeat length, the researchers adapted single-cell RNA-sequencing to help ...

Huntington’s disease stems from a mutation in the HTT gene, which includes a repetitive sequence of DNA known as the CAG repeat. While healthy individuals have between 15 and 35 CAG repeats ...

People genetically susceptible to Huntington’s disease often see their movement ... This happens repeatedly until the CAG/CTG repeats expand enough to interfere with the function of the huntingtin ...

HDBuzz reported live updates on Bluesky from the 2025 HD Therapeutics Conference. Read on for coverage of Day 2. #CHDI2025 ...