research suggests that certain dopaminergic pathways may also be important in relieving depression-like symptoms. Research in humans has demonstrated that for some individuals with treatment-resistant ...

This is because dopamine plays a crucial role in emotional regulation through the “mesolimbic dopaminergic pathway,” which governs reward-related behavior and stress responses. When you engage ...

Northwestern Medicine investigators have uncovered new insights into how metabolic dysfunction contributes to Parkinson's ...

Learn more about eLife assessments Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded.

A subset of Parkinson’s disease is caused by CHCHD2, a gene which encodes a protein contained in the mitochondria of cells.

in particular those associated with the nigrostriatal dopaminergic pathway. There is now robust experimental evidence for a neuroprotective effect of nicotine upon dopaminergic neurons.

Precision drugs and gene therapy treatments to activate pro-survival pathways in selected neuronal populations We investigate molecular mechanisms promoting functional maintenance of dopaminergic ...