For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ordinary ...

Biologists are closing in on a puzzle that seems to turn classic evolutionary logic inside out, yet may be so common that it ...

A study published in the Proceedings of the National Academy of Sciences by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Throughout most of human history, evolution progressed slowly. Small genetic changes took thousands of years to permeate populations. Natural selection was intentional, reactive, and gradual. However, ...

The ability to evolve proteins with new or improved functions provides powerful applications for the development of selective, high-affinity antibodies, enzymes with new catalytic properties, and the ...

ANN ARBOR—For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

A groundbreaking study published in this week’s issue of PNAS by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not randomly but more ...