NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

Jason Logan breaks down his early 49ers vs. Colts predictions and explains why there's value backing the home underdog. Free NFL picks for December 22.

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

Richard Sherman speaks about the San Francisco 49ers and Brandon Aiyuk situation as the wideout's time with the team could be ending.

San Francisco 49ers stars Christian McCaffrey and Kyle Juszczyk both sit atop their positions in Pro Bowl fan voting.

The 49ers will look to carry that momentum into Week 16 when they hit the road for a matchup against the Indianapolis Colts. San Francisco is set to face veteran quarterback Philip Rivers, who recently came out of retirement to replace Daniel Jones after the Colts' starter suffered a season-ending Achilles injury.

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

The San Francisco 49ers are a National Football League team that plays in the NFC West division. The 49ers have won five Super Bowl titles over the course of their history.

Yahoo Sports Daily hosts Caroline Fenton and Jason Fitz discuss why the San Francisco 49ers are the best story in the NFL this season. Watch the full episode of Yahoo Sports Daily on YouTube or YahooSports.

The San Francisco 49ers officially will face off against Philip Rivers in Week 16 against the Indianapolis Colts.

When Daniel Jones went down for the season with a torn Achilles, the 49ers probably figured their upcoming game against the Colts would be an easy win.