The intracellular distribution of a drug can cause significant variability in both activity and selectivity. Herein, we investigate the mechanism by which the anti-cancer agents, di-2-pyridylketone ...

This is a preview. Log in through your library . Abstract Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of ...

Patients with nonvalvular atrial fibrillation and normal kidney function had increased bleeding risk with dabigatran when used alongside P-glycoprotein inhibitors diltiazem and verapamil, according to ...

Severe acute respiratory syndrome virus 2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), uses its spike (S) glycoprotein to enter host cells. The S glycoprotein consists of ...

IgG subclasses differ in their effector functions in a variety of in vitro assays. To assess the effect of antibody subclass differences on in vivo protective efficacy against herpes simplex virus ...