Researchers have developed a human intestinal cell model that closely mimics the structure and function of the human gut, enabling more precise prediction of drug-induced gastrointestinal toxicity ...

All animals possess some capacity for repairing and replacing the lining of their intestines, a process called intestinal regeneration. In mammals, including humans, this constant but relatively minor ...

Intestinal tuft cells divide to make new cells when immunological cues trigger them. Additionally, in contrast to progenitor- and stem cells, tuft cells can survive severe injury such as irradiation ...

Miniature organs grown in the lab can organize themselves into complex shapes, which enables scientists to use them to study disease. The trouble is they never do it the same way twice, which has made ...

Intestine-Mimicking Cell Model Accurately Predicts Drug Toxicity KRIBBs hIEC model detects gastrointestinal toxicity with 94% accuracy, offering early prediction of drug side effects ...

The human gastrointestinal tract is in a constant state of flux; it hosts a diverse and dynamic community of microbes known as the gut microbiome, and is constantly exposed to things in the ...

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

Organ-Chips as a Platform for Studying Effects of Space on Human Enteric Physiology (Gut on Chip) examines the effect of microgravity and other space-related stress factors on biotechnology company ...

Thanks to lab-grown miniature intestines, researchers at Uppsala University have successfully mapped how aggressive Shigella bacteria infect the human gut. The study opens the door to using cultured ...

A study of about 15,000 adults finds a lasting association between the use of certain antibiotics and the balance of the ...

Intestinal tuft cells divide to make new cells when immunological cues trigger them. Additionally, in contrast to progenitor- and stem cells, tuft cells can survive severe injury such as irradiation ...