GABAergic interneurons play key roles in cortical circuits, yet little is known about their early connectivity. Here we use glutamate uncaging and a novel optogenetic strategy to track changes in the ...

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that ...

Researchers have developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 10 (May 15, 1989), pp. 3911-3914 (4 pages) We used a passive, steady-state cable model to simulate current ...

A new study reveals how interneurons, dubbed 'the butterflies of the soul,' emerge and diversify in the brain. The findings may help inform the development of new classes of drugs for diseases such as ...

An LSU Health New Orleans research study led by Siqiong June Liu, PhD, Professor of Cell Biology and Anatomy, has found that cerebellar inhibitory interneurons are essential for fear memory, a type of ...

One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited, firing overtime and ultimately being poisoned by their own activity (Rao ...

Labeling of intraregional synapses using LCD-eGRASP in the basolateral amygdala (BLA). Engram cells (Red), Non-engram cells (White), synapses from activated inhibitory interneurons (yellow), and ...

A key receptor regulating memory formation has been localized to interneurons, according to a study with implications for drug development. Robert Pearce and colleagues probed the localization of ...

Neurons are the fundamental units of the brain and nervous system and a mammalian brain contains between 100 million and 100 billion neurons, depending on the species. Roughly 100 billion neurons do ...