The knee-jerk reflex, that sudden and involuntary extension of your lower leg when the area below your kneecap is tapped, ...

The analysis of the human brain is a central goal of neuroscience. However, for methodological reasons, research has largely focused on model organisms, in particular the mouse. Now, neuroscientists ...

Exactly 200 years after the discovery of the trace element selenium, researchers have shown for the first time why this chemical element is indispensable for mammalian life. As integral part of the ...

Researchers have developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a ...

The expression "once bitten, twice shy" is an illustration of how a bad experience can induce fear and caution. How to effectively reduce the memory of aversive events is a fundamental question in ...

Researchers at the University of Virginia School of Medicine have uncovered how problems in cortical microcircuits in the brain can trigger epileptic seizures. The researchers say that targeting the ...

This is a preview. Log in through your library . Abstract The tight balance between synaptic excitation and inhibition (E/I) within neocortical circuits in the mammalian brain is important for complex ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 10 (May 15, 1989), pp. 3911-3914 (4 pages) We used a passive, steady-state cable model to simulate current ...

An LSU Health New Orleans research study led by Siqiong June Liu, PhD, Professor of Cell Biology and Anatomy, has found that cerebellar inhibitory interneurons are essential for fear memory, a type of ...

One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited, firing overtime and ultimately being poisoned by their own activity (Rao ...