We propose the warped linear mixed model (WarpedLMM), a principled generalization of the standard LMM that allows to fit phenotype transformations while performing genetic analyses.

However, the utility of linear (mixed) models in the context of meta-analysis of GWAS of binary phenotypes has not been previously explored.

Then we describe three common applications of the linear mixed model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability ...

The methodology will be illustrated for linear mixed models in the analysis of 22-dimensional, highly unbalanced, longitudinal profiles of hearing thresholds. Biometrics is a scientific journal ...