The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...

Research has uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile structures at the inner face of the ...

The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study. The flow of water within a muscle fiber may dictate how quickly muscle can contract, ...

Muscle thermodynamics; bioengineered muscle systems; molecular mechanisms of muscle contraction and regulation; mechanochemistry of molecular motor ensembles; single molecule and whole cell imaging; ...

BOULDER, Colo.--(BUSINESS WIRE)--Edgewise Therapeutics, Inc., (Nasdaq: EWTX), a clinical-stage biopharmaceutical company focused on developing orally bioavailable, targeted, small molecule therapies ...

There’s a big knowledge gap when it comes to understanding how muscles control movement in daily life, according to Monica Daley. So, the University of California, Irvine professor told the Business ...

Skeletal muscle cells facilitate voluntary movements such as walking, running, and other forms of exercise. They are comprised of thin, tubular cells called muscle or myofibres due to their threadlike ...