The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

The backup candidate compound, VU6007496, is a positive allosteric modulator—a PAM—for a neurotransmitter receptor called M 1 muscarinic acetylcholine receptors. PAMs selectively bind to a ...

It stimulates specific acetylcholine receptors (called muscarinic receptors) in the brain while limiting stimulation of these receptors in the peripheral nervous system (for example, in the ...

Xanomeline works by targeting two specific receptors in brain cells, M1 and M4, which are part of the muscarinic acetylcholine system. Trospium chloride helps by blocking xanomeline from ...

Cholinergic drugs (acetylcholine and methacholine ... both events explain the increase in airway resistance. Muscarinic (M) receptors involved in the airway tone regulation are as follows ...

Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate, and are hypothesised to be dysfunctional in schizophrenia. Most drugs developed to treat schizophrenia to ...

Homatropine is an anticholinergic that inhibits activity of the muscarinic acetylcholine receptor with less potency than atropine. Abuse potential (monitor). Life-threatening respiratory ...

Antagonizes of the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Parasympatholytic activity reduces the tonus of smooth muscle in the ...