A Nature Neuroscience study in mouse models and human multiple sclerosis tissue identifies a pro-inflammatory microglial state marked by lysosomal cholesterol accumulation that drives chronic ...
What makes the aging brain vulnerable to memory loss? In the August 11 Neuron, scientists led by Li Gan at Weill Cornell Medicine, New York, laid some of the blame on senescent microglia. In a mouse ...
The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan. Furthermore, the A4G47 peptide from the E8 region of laminin-411 was found ...
Researchers at Institute of Science Tokyo have identified laminin-411 and A4G47, a synthetic peptide derived from the E8 domain of laminin-411 protein, as the key factors in the maturation of ...
Researchers from Tel Aviv University have discovered a new biological mechanism that enhances the production of myelin—a substance essential for proper brain function and nerve communication. "Our ...
Alzheimer’s disease damages myelin, but exactly what it does to this insulating material remains somewhat mysterious. In the June 13 Nature Neuroscience, scientists led by Jaime Grutzendler at Yale ...
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