New research published in The FEBS Journal reveals the importance of a protein called ... C1QL1 protein identified as key to myelin replacement. 1mo. ... Our basic research on C1QL1 is nascent, ...

Investigators in our division conduct both basic and clinical research in the areas of experimental allergic encephalomyelitis, immunological and structural studies of the idiotypic network in ...

The myelin sheath of nerve fibers was first discovered and described by Rudolf Virchow in 1854. Myelin is composed of about 40% water and the dry mass is composed of about 80% lipids and 20% protein.

Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients: a marker of activated/memory T cells. J Clin Invest 1998;101:725-730 ...

Targeted stimulation of Nfat proteins could perhaps be used in the future to promote the formation of new myelin sheaths in MS patients, for example after a relapse. However, such stimulating ...

Rather, the team found, the RNA latches on to a protein called SOX10, and together they turn on production of myelin basic protein, which zips myelin into a tight sleeve around nerve cells.

The RNA/protein combination binds to DNA near the gene for myelin basic protein, or MBP, a major component of myelin. “MBP is essential for the membrane growth and compression of ...

The neurons of the brain are protected by an insulating layer called myelin. ... C1QL1 protein identified as key to myelin replacement. Download PDF Copy; ... Our basic research on C1QL1 is ...

Expression of myelin basic protein (MBP)—the building block of myelin sheaths—was also lower in the hippocampi of older mice. Wielding a menagerie of mouse models, the researchers went on to reveal ...