Before this diagnosis in China, the youngest patient with Alzheimer's was 21 years old. They carried the PSEN1 gene mutation, ...

The teenager, diagnosed with Alzheimer's disease, was having trouble focusing in class. While reading became difficult, his ...

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

For many years, Arboleda-Velasquez and an international team of scientists have been studying a large cohort of related individuals in Colombia who have ADAD caused by a mutation called PSEN1-E280A.