In an exceptionally rare case, a patient with a high genetic risk of developing Alzheimer's appears to have avoided his probable fate for decades, according to new research. The man's situation is ...

One genetic variant associated with Alzheimer’s disease progression is presenilin 2 (PSEN2), which is correlated to an increased risk for early-onset familial Alzheimer’s disease (EOFAD).

Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant ...

Since 2011, a study called the Dominantly Inherited Alzheimer Network (DIAN) has been following a family in which many members have a mutation in a gene called PSEN2. The mutation causes the brain ...

The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.

Despite carrying a dominant Presenilin 2 (PSEN2) p.Asn141Ile mutation, a known genetic link to Alzheimer's disease (AD), the participant displayed no AD symptoms even 18 years beyond the expected ...

Researchers estimate there are at least 80 genetic areas that may play a role in the progression of Alzheimer’s disease, including presenilin 2 (PSEN2) located on chromosome 1. Researchers from ...