Familial Alzheimer's disease (FAD), a rare inherited form of the disease, is linked to mutations in several genes, including APP, PSEN1, and PSEN2. The impact of PSEN2 mutations has remained less ...

The impact of PSEN2 mutations has remained less understood-; until now. A research team led by Prof. Wim Annaert at VIB-KU Leuven has shed light on how mutated PSEN2 accelerates disease ...

The impact of PSEN2 mutations has remained less understood—until now. A research team led by Prof. Wim Annaert at VIB-KU Leuven has shed light on how mutated PSEN2 accelerates disease ...

The PSEN1 and PSEN2 genes encode similar proteins that act as core parts of a complex enzyme system called γ-secretase. This system cuts the APP protein into smaller fragments called amyloid-beta ...

We have analyzed the 5′-upstream promoter region of the presenilin 2 gene (PSEN2) for regulatory elements and examined Alzheimer disease (AD) patients and non-demented individuals for ...

PSEN2 mutations are associated with an accumulation of the protein amyloid-beta in the brain, which is currently considered a hallmark of Alzheimer’s disease, as well as an increased risk for ...

Remarkably, PSEN2 KO worsens amyloid pathology in the APP KI mice, which is ascribed to the increased ability of PSEN1 to secrete Aβ in the setting of PSEN2 KO. The PSEN2 FAD mutation causes elevated ...

The mutation appears to reduce PSEN2 stability. Mutant transcript levels were reduced more than fourfold and mutant protein levels were approximately 50 percent reduced compared with those of ...

A group of researchers in the lab of Prof. Lucía Chávez Gutiérrez (VIB-KU Leuven) have unraveled the genetic contributions to familial Alzheimer's Disease development and revealed how specific ...

Alzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in molecular networks linking a host of biological processes. A variety of genetic ...