Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide. Familial Alzheimer's disease (FAD), a rare ...
Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow). When the PSEN2 gene is absent or carries a familial Alzheimer-related mutation (middle), the lysosomes ...
Evidence from epidemiological studies suggesting a potential protective effect of anti-inflammatory drugs in Alzheimer's disease (AD) have not been supported by therapeutic studies using nonsteroidal ...
We have analyzed the 5′-upstream promoter region of the presenilin 2 gene (PSEN2) for regulatory elements and examined Alzheimer disease (AD) patients and non-demented individuals for polymorphisms in ...
Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant ...
In an exceptionally rare case, a patient with a high genetic risk of developing Alzheimer's appears to have avoided his probable fate for decades, according to new research. The man's situation is ...
Both presenilin-1 or the less-studied presenilin-2 can act as the catalytic subunit of γ-secretase, the enzyme responsible for churning out Aβ peptides. A new study, published November 29 in Nature ...
Alzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in molecular networks linking a host of biological processes. A variety of genetic ...
These mice lack PSEN2; no gene product (mRNA or protein) is detected by Northern or Western blot analysis. Homozygous mice are viable, born at expected Mendelian frequency, and fertile. They are ...
The slow loss of memory, thinking, and independence that defines Alzheimer’s disease continues to affect millions worldwide. One rare but revealing form of the condition, known as familial Alzheimer’s ...
Abstract Genetics of Alzheimer's Disease and Dementia Genetic Diagnosis, Counselling of AD, and Dementia Clinical Implications for New Drug Development References Genetic Diagnosis, Counselling of AD, ...
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