Skeletal muscle is integral to whole-body homeostasis, enabling movement and contributing substantially to metabolic regulation. Recent advances have illuminated the ability of muscle tissue to adapt ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Skeletal muscle is pivotal not only for movement but also for systemic metabolic regulation. Its physiology encompasses intricate networks of contractile machinery, mitochondrial dynamics, and ...