DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...
In gene therapy, promoters act as vital “on/off” switches, dictating whether a therapeutic gene is active and to what extent. While delivery vehicles such as adeno-associated viruses (AAVs) can bring ...
The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within regulatory ...
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