showed that in this posterior lateral region of the cerebellum, the activity of neurons called Purkinje cells changes to reflect the process of learning visuomotor associations according to reward ...

Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ...

In this case, we combine electrophysiology, multi-photon imaging, and biophysical modeling to understand the computational function of changes in intrinsic excitability in cerebellar Purkinje cells.

Previously, the group investigated two models of dystonia, a different motor disorder, and demonstrated that preventing brainstem neurons from communicating with the cerebellum disturbed ... team ...

White JJ, Arancillo M, Stay TL, et al. Cerebellar zonal patterning relies on Purkinje cell neurotransmission. J Neurosci. 2014;34(24):8231-45. White JJ, Sillitoe RV. Development of the cerebellum: ...