Defective viral genomes (DVGs) and defective interfering particles (DIPs) represent naturally occurring variants of RNA viruses that are incapable of autonomous replication. In the presence of a ...

ST. LOUIS – Hepatitis B virus, a killer of more than one million people each year, is a notoriously wily virus, often lingering and resurfacing even after treatment. But, thanks to a new class of ...

A virus lacks sensory organs, so it uses chemical cues to determine how it replicates its genetic material into new viral packages or assemblies with precise polarity. This polarity guides the RNA, ...

"Our study builds on the discovery of RNA interference, for which the Nobel Prize in Medicine was awarded in 2006. While siRNA therapies have already been used for genetic diseases, our work is the ...

RNA interference (RNAi) therapeutics have garnered significant attention in clinical research due to their potential for treating various diseases, including genetic disorders, viral infections and ...

Researchers have discovered RNA mechanisms that may lead to more effective, durable and targeted treatments for conditions like high cholesterol, liver diseases and cancers. RNA interference (RNAi) ...

Researchers used advanced imaging techniques, conducted at Penn State’s publicly funded Core Facilities, to study the architecture of the Turnip Crinkle Virus (TCV). This plant pathogen has an ...

Highly pathogenic avian influenza A(H5N1) viruses are circulating among wild birds and poultry in British Columbia, Canada. 1 These viruses are also recognized to cause illness in humans. Here, we ...