Clinical studies have shown that periodontal disease with Aggregatibacter actinomycetemcomitans can exacerbate symptoms of rheumatoid arthritis (RA), but the molecular mechanisms behind this remain ...

Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the endoplasmic reticulum. Dysregulation of PDIs has been ...

Periodontal disease, which affects the gums and tissues that surround the teeth, is one of the most prevalent dental conditions worldwide. Most often caused by the formation and accumulation of ...

RA FLSs, PBMCs, and THP-1 cells were treated with vehicle control and different concentrations of EFC for 72 h (a) or 24 h (b). (a) The cell number was measured using the CCK-8 assay, and IC50 values ...

A groundbreaking scientific perspective is reshaping how researchers understand rheumatoid arthritis, a debilitating autoimmune condition that affects nearly 1.3 million Americans. Recent studies have ...

Researchers unveil mechanism by which periodontal bacterium A. actinomycetemcomitans exacerbated symptoms of rheumatoid arthritis (RA) conducted various experiments in a mouse model of rheumatoid ...