The sarcomere is the most basic contractile unit in skeletal and cardiac muscle. Mutations in genes encoding sarcomeric proteins give rise to heritable myopathies, although muscle function is more ...

The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial disorder that results in reduced contractile function, is largely unknown. Some cases of familial dilated cardiomyopathy ...

Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic pathways are activated early, before ...

The basic functional unit of a muscle, known as the sarcomere, consists of actin, myosin and tropomyosin proteins. If a muscle is to be able to contract, the myosin must slide along filamentous actin ...

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, using electron cryo-tomography (cryo-ET). The international ...

This is a preview. Log in through your library . Abstract Each muscle cell of the syllid (Annelida: Polychaeta) proventriculus, the region of the gut posterior to the pharynx, contains a single ...