How do we think, feel, remember, or move? It all depends on transmission of chemical signals in the brain, carried and released by molecular containers called vesicles. In a new study, researchers ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 25 (June 23, 2020), pp. 14493-14502 (10 pages) A high rate of synaptic vesicle (SV) release is required ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Parkinson's and Alzheimer's diseases are the two most common neurodegenerative disorders, affecting millions of people ...

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a stable level that reflects the speed of replenishment of the readily releasable pool (RRP). Determining the ...

Jose Rizo-Rey is a professor of biophysics at the University of Texas Southwestern Medical Center. He is using the fastest academic supercomputer in the U.S. to study an important process that helps ...

Researchers have uncovered a shared brain cell breakdown mechanism behind Alzheimer’s and Parkinson’s diseases, revealing how ...

Parkinson's and Alzheimer's diseases are the two most common neurodegenerative disorders, affecting millions of people ...

Eye-specific differences in presynaptic release site addition and clustering correlate with axonal segregation outcomes during retinogeniculate refinement in the mouse.

Video depiction of vesicle fusion and tethering. In the active zone in the central left of the video, docked vesicles (dark blue) fuse with the membrane, releasing their contents and being quickly ...