How do we think, feel, remember, or move? It all depends on transmission of chemical signals in the brain, carried and released by molecular containers called vesicles. In a new study, researchers ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 25 (June 23, 2020), pp. 14493-14502 (10 pages) A high rate of synaptic vesicle (SV) release is required ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Researchers at Johns Hopkins Medicine say they unexpectedly found new information about a protein’s special role in getting brain cells to communicate at the right time and place in experiments with ...

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a stable level that reflects the speed of replenishment of the readily releasable pool (RRP). Determining the ...

Researchers developed a new PET tracer capable of measuring synapse loss after spinal cord injury, offering insights into both spinal and brain changes.

Tomosyn's tight regulation of neurotransmitter release distinguishes functions of two neuron classes at the fly neuromuscular junction, incluiding their ability to engage in a form of plasticity The ...

Video depiction of vesicle fusion and tethering. In the active zone in the central left of the video, docked vesicles (dark blue) fuse with the membrane, releasing their contents and being quickly ...