The vesicle cycle describes the steps through which neurotransmitters (chemical signals) are released at a synapse (a ...

Homeostatic plasticity, the brain's method of preserving equilibrium in neural circuits, relies heavily on spontaneous ...

The vesicles themselves inside the giant synapse are not larger, but it is much easier to follow their individual paths within the huge synapse. The real challenge was to establish a method to ...

The process of recycling at a synapse. First, lipid membrane capsules are recovered from the pre-synaptic terminal membrane. Then, the vesicles are refilled with neurotransmitter.

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons ...

But vesicle fusion is thought to be triggered by the much higher Ca 2+ concentrations (more than 100 μM) near the open mouth of individual Ca 2+ channels 6 . It now appears 2 , 3 that such high ...

Synaptic vesicles in presynaptic terminals are classified in sub-populations or pools on the basis of function 1,2,3,4,5,6.As such, the properties of these pools, their size, physical organization ...

T here is very little about membrane vesicle fusion that Yale University biochemist James Rothman doesn’t know—he codiscovered SNAREs, the proteins that orchestrate the process. But one unanswered ...

For the first time, scientists at Weill Cornell Medical College in New York City have observed in real time a cellular mechanism that's crucial to how brain cells communicate.

When a synapse becomes active, some of these vesicles fuse with the cell membrane and release their contents. To ensure that valuable time is not lost, synapses always have some readily releasable ...

Vesicle cycle model reveals inner workings of brain synapse. ScienceDaily . Retrieved July 12, 2025 from www.sciencedaily.com / releases / 2025 / 05 / 250528150657.htm ...