Current therapies for rheumatoid arthritis rely on sustained immunosuppression rather than restoration of immune tolerance, with off-drug remission remaining rare.
T cells are some of the immune system's most important warriors. They can stop tumor growth and even fight off severe ...
Researchers found that lowering MHC I can expose cancerous or foreign cells to CD4+ T cell attack, reshaping assumptions ...
LONDON -- Most patients with super-refractory, seropositive rheumatoid arthritis (RA) responded well to chimeric antigen receptor (CAR) T-cell therapy in the first part of an ongoing phase I/II trial, ...
A new study reveals a possible way to make CAR T-cell therapy more durable and effective by targeting a single ...
CAR T-cell therapy has been hugely successful in treating certain types of tumours, and stiffening up cancer cells beforehand could make it even more effective ...
The cost of CAR T-cell therapy means that the highly effective cancer treatment is unavailable in many parts of the world.
Formation of an immunological synapse (gray) between CAR-T cells, which are specially equipped to express the CCR7 receptor(cyan), and tumor cells (magenta). The CAR ...
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