Primary immunodeficiencies are genetic disorders that impact on the immune system due to defective function of a variety of genes. Among those molecules are ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Nerve cells are not just nerve cells. Depending on how finely we distinguish, there are several hundred to several thousand different types of nerve cell in the human brain according to the latest ...

Hyperactive signaling pathways of some aggressive blood cancer cells can be tamped down by a previously unrecognized protein complex, ensuring the cancer's survival. If one component of the complex is ...

Immunometabolism has emerged as a central hub linking infection, inflammation, cell death, and cancer. The metabolic state of cells profoundly shapes their ...

A UCLA study found that macrophages rely on interferon gamma signaling from past infections to preserve innate defenses.

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...