The AHA recommended whole exome or whole genome sequencing as first-line diagnostic tools for mitochondrial diseases.

A new study from deCODE genetics uses pedigrees and sequence data from 64,806 Icelanders to shed light on the rate and nature of mutations in mitochondrial DNA (mtDNA) and the peculiar dynamics of its ...

You are a forensic scientist recruited to help solve a long-standing "missing persons" case. Mitochondrial DNA, or mtDNA for short, is the key to your success. Take careful notes as your teacher ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Provide each team with a copy of "The Hunt for mtDNA" student handout. Explain to students what mtDNA is, how it differs from nuclear DNA, and how it is inherited (see Activity Answer for more ...

Mitochondria act as energy factories in cells and have their own, separate DNA. Mutations to mitochondrial DNA (mtDNA) have been observed in cancer, but it has been unclear how these changes might ...

There are a total of 5 multi-subunit complexes in the inner membrane of the mitochondria, all of which are involved in the process of oxidative phosphorylation that precedes ATP production. Of these, ...

When a four-year-old boy was brought to the Cincinnati Children’s Hospital Medical Center with fatigue, muscle pain and muscle weakness, doctors suspected there might be something wrong with his ...

Mitochondrial genomes are not uniform across cells of the body as previously believed, but vary between different tissue types, according to a study published online today (March 3) in Nature. Image: ...