A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in ...

Huntington's disease is a neurodegenerative disorder that is usually fatal about 15 to 20 years after a patient is diagnosed. It is known ... | Genetics And Genomics ...

Less than a month after researchers unveiled that a “ticking DNA clock” is behind Huntington’s disease (HD), scientists have ...

Symptoms of Huntington's disease appear late in life. Research reveals how DNA repeats grow toxic over time, explaining the delayed onset and disease variability.

It is an especially relevant question for many living with Huntington’s Disease (HD). Notably, some studies have shown that ...

Huntington's disease kills a population of cells called striatal projection neurons, which are located in the striatum, a structure deep in the brain responsible for movement, many cognitive ...

11, 2025 — A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons ... in Huntington's disease and ...

Huntington's disease, which affects about 30,000 Americans ... But striatal projection neurons — the primary striatal cells that die in the disease — had greatly expanded their CAG-repeat ...

Study uncovers how gradual CAG repeat expansion in neurons drives the onset of Huntington’s disease, offering new insights for potential therapeutic interventions. Study: Long somatic DNA-repeat ...

The cells seem to die once the CAG repeat reaches about 150 times. As these mutation-carrying neurons die off, the symptoms of the disease arise. Therapies that aim to treat Huntington's by reducing ...

Using CRISPR technology, scientists uncovered genes that control C-A-G genetic stumbles in Huntington's disease ...