Scientists have uncovered how a protein helps build and maintain vital brain connections, providing insights into the ...

This important study demonstrates the significance of incorporating biological constraints in training neural networks to develop models that make accurate predictions under novel conditions. By ...

Researchers are developing promising suppression systems for painful conditions—even an app on your phone that turns the pain off.

Dravet syndrome (DS) is a rare and severe form of epilepsy that causes intellectual disability and motor deficits and can lead to premature death. A loss-of-function mutation in one copy of SCN1A, ...

Of inhibitory neurons in the cerebral cortex, the majority (60%) are parvalbumin-positive neurons. These inhibitory cells have control over plasticity in the brain, affecting the time period in which ...

Scientists analyzed 3.4 million cells from 84 donor brains and created a detailed map of the damage that occurs during the disease, which is the leading cause of dementia for people 65 and older ...

Mathew isn’t claiming that the two systems—larval Keystone inhibitory neuron being modulated by insulin and the human basal ganglia inhibitory neurons being modulated by dopamine—are exactly the same, ...

Rajasekaran, K., et al. (2022) Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency. Science Translational Medicine ...

Inhibitory neuron activity prevents the brain from getting over-excited. If a scientist represses the inhibitory neuron activity, the neurons become more active, but it can cause toxicity.

In a new study, scientists detail how they coaxed excitatory neurons to release neurotransmitters usually produced by inhibitory neurons.

To hunt for this neuron, the team recorded neuronal activity from identified cell types in brain slices. They found a significant reduction in connectivity between pyramidal cells and a subset of ...

The murine study, by scientists at the Max Planck Florida Institute for Neuroscience, focused on chandelier cells (ChC), a type of inhibitory neurons in the cortical section of the brain, and ...