Pup brains were examined at P7 for myelin basic protein (MBP) in the internal and external capsules using immunohistochemistry. ... MBP mRNA expression was also markedly suppressed.

The neurons of the brain are protected by an insulating layer called myelin. ... Our basic research on C1QL1 is nascent, ... (2024) C1ql1 expression in oligodendrocyte progenitor cells promotes ...

What exactly is myelin? Myelin is a concentrically laminated membrane structure surrounding an axon around which lamellae (or cellular protrusions) repeat radially at a period of about 12 nm ...

A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression. Cell , 2024; 187 (4): 814 DOI: 10.1016/j.cell.2024.01.011 Cite This Page : ...

Kedia and colleagues found the Serpina3n oligodendrocytes had swelled with myelin basic protein (MBP), and their processes had fragmented, suggesting they were ... they attacked and engulfed the ...

The aim of the new project was to understand how the identified proteins interact when myelin is formed. ... The findings are not only relevant to basic research, but also to medicine.

The RNA/protein combination binds to DNA near the gene for myelin basic protein, or MBP, a major component of myelin. “MBP is essential for the membrane growth and compression of ...

A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression. Cell . Published online February 15, 2024. doi: 10.1016/j.cell.2024.01.011.

An adeno-associated virus-2 (AAV2)-coding human P301S mutant tau protein (AAV2-tau-P301S) was injected into hippocampal tissues of 10-month-old fE murine animals, and tau spread from the injected ...

The myelin sheath of nerve fibers was first discovered and described by Rudolf Virchow in 1854. Myelin is composed of about 40% water and the dry mass is composed of about 80% lipids and 20% protein.

The researchers noted this effect in the APOE3 coculture, “but in the APOE4 coculture, we saw much-reduced . . . myelin basic protein signature,” she says, indicating less myelin production.

In this image, an axon appears in green, while abnormal protein clumps (amyloid, red) lodge in tiny channels within the myelin sheath. Amyloid aggregates form filament-like strands across the ...