Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple sclerosis. The myelin basic protein peptide (a.a. 83–99) represents one candidate antigen; therefore, it ...

Protein makeup differs in Alzheimer's disease Different cell types are impacted by Alzheimer's disease in different ways, and oligodendrocytes are especially vulnerable to the disease.

University of Pennsylvania researchers have developed a powerful new investigative tool to reveal how proteins work inside living cells. A technique that enables quick, precise and minimally ...

In cultured vascular smooth muscle cells, angiotensin II (Ang II) stimulated a cytosolic protein kinase activity toward myelin basic protein (MBP) in a time- and dose-dependent manner. Phorbol 12-myr ...

Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In ...

New research published in The FEBS Journal reveals the importance of a protein called C1QL1 for promoting the replacement of the specialized cells that produce myelin.

Kedia and colleagues found the Serpina3n oligodendrocytes had swelled with myelin basic protein (MBP), and their processes had fragmented, suggesting they were overwhelmed with myelin. Scanning ...

Proteins let cells remember how well their last division went Scientists find a "mitotic stopwatch" that lets individual cells remember something.

A retrovirus embedded in the DNA of some vertebrates helps turn on production of a protein needed to insulate nerve cells, aiding speedy thoughts.

Ancient retroviruses played a key role in the evolution of vertebrate brains Date: February 15, 2024 Source: Cell Press Summary: Researchers report that ancient viruses may be to thank for myelin ...

In rodents, the researchers found that the RNA transcript of RetroMyelin regulates the expression of myelin basic protein, one of the key components of myelin. When they experimentally inhibited ...

After all, these specialized cells wrap cholesterol-laden myelin around axons in the brain's white matter beginning early in development, and throughout life they sustain and repair this insulation.