Previously, researchers found that after an experimentally induced stroke (with temporary or permanent blockage of the middle cerebral artery), functional outcomes in rodents improved if they received ...

Subsequent sequencing analysis of the miRNAs within these vesicles revealed that M-Ang2-EVs enhance microglial phagocytosis of myelin, promote axonal remyelination and extension, and regulate tight ...

View Full Profile. Learn about our Editorial Policies. Rational design is the classical protein engineering method that involves site directed mutagenesis. 7 Scientists perform specific point ...

Western blotting allows scientists to identify specific proteins in complex biological samples and determine relative abundance of a protein target ... blot assay has a multitude of applications, from ...

Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins ...

Current methods for measuring protein activities use drugs or genetic approaches that switch off the target protein’s activities everywhere in the cell. Now, Bucko et al. have developed a new tool ...

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress ...