† Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, United States ‡ Department of Chemistry & Biochemistry, Ohio State University, Columbus, Ohio 43210, ...

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly ...

Heart failure with preserved ejection fraction (HFpEF) is a major public health challenge, affecting millions worldwide and placing a significant burden on healthcare systems due to high ...

Using invasive pressure-volume loops, takotsubo syndrome (TTS) is associated with impaired cardiac contractility and a shortened systolic interval (with increased LV diastolic volume compensating for ...

Titin, the largest protein known, forms an elastic myofilament in the striated muscle sarcomere. To establish titin’s contribution to skeletal muscle passive stiffness, relative to that of the ...

In the not too distant past, myofilament research attracted considerable attention after the discovery that mutations in myofilament genes cause cardiomyopathies. However, basic research has not been ...

Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited ...

Heart failure and cardiac arrhythmias are the leading causes of mortality and morbidity worldwide. However, the mechanism of pathogenesis and myocardial malfunction in the diseased heart remains to be ...

Heart failure remains a huge health care burden, with one in nine death certificates in the United States listing it as the cause of death. 1 Medical therapy has improved the prognosis for patients ...