† Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, United States ‡ Department of Chemistry & Biochemistry, Ohio State University, Columbus, Ohio 43210, ...

Coexistence of >1 cTnT variant results in a temporally split myofilament response to calcium impairing contractility. Analysis of healthy human hearts showed an association between rs1786814 GG ...

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly ...

Using invasive pressure-volume loops, takotsubo syndrome (TTS) is associated with impaired cardiac contractility and a shortened systolic interval (with increased LV diastolic volume compensating for ...

Human heart failure is defined as the inability of the cardiac pump function to meet peripheral demands. Heart failure afflicts ∼6 million patients in the US and is associated with 1 in 9 deaths ...

Rationale Myofilament proteins are responsible for cardiac contraction. The myofilament subproteome, however, has not been comprehensively analysed thus far. Methods Cardiomyocytes were isolated from ...

A new study reveals how, on a cellular level, diabetes can cause heart failure. The findings could lead to medications to treat and perhaps prevent heart failure in diabetes patients. Men with ...

We are grateful to H. Lum and L. Carrier for providing Ad-PKI and the antibody against cMy-BPC, respectively. We are grateful to Aurore Germain, Florence Lefebvre, Guillermo Salazar, Patrice Bideaux, ...