The logistics underlying myofilament assembly and disassembly have started to emerge with the possibility to follow labeled sarcomere components. Here, we generated the mCherry knock-in at titin’s ...

Citation: Dominic KL, Schmidt AV, Granzier H, Campbell KS and Stelzer JE (2024) Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF.

Researchers investigated the impact of aldosterone infection in db/db mice on HFpEF, focusing on sex differences and alterations in intracellular calcium handling and cardiomyocyte electrophysiology.

TTS is characterized by reduced cardiac contractility, a shortened systolic period, inefficient energetics, and prolonged active relaxation but unaltered diastolic passive stiffness. The authors ...

Overview of myofilament phosphorylation changes and potential upstream kinases. Shown are the represented GO functions in percent for proteins significantly changed in heart failure with preserved ...

Additional work is needed to address other myofilament properties, including dynamic response to calcium transients, myofilament efficiency, thin and thick filament dynamics, and relaxation kinetics, ...

Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through myofilament Ca2+ sensitivity. Here, we ...

A recent study using a dog model of heart failure showed that cardiac resynchronization therapy seems to be mediated by the phosphorylation of myocyte proteins by glycogen synthase kinase 3β.