† Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, United States ‡ Department of Chemistry & Biochemistry, Ohio State University, Columbus, Ohio 43210, ...

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly ...

Cardiac muscle contraction is finely regulated by the concerted action of thin- and thick-filaments. Pathogenic variants in cardiac thin-filament (cTF) proteins associated with cardiomyopathies ...

Human heart failure is defined as the inability of the cardiac pump function to meet peripheral demands. Heart failure afflicts ∼6 million patients in the US and is associated with 1 in 9 deaths ...

To produce and validate myofilament-restricted Ca 2+ imaging probes in an adenoviral transduction adult cardiomyocyte model using drugs that alter myofilament function (MYK-461, omecamtiv mecarbil, ...

Titin, the largest protein known, forms an elastic myofilament in the striated muscle sarcomere. To establish titin’s contribution to skeletal muscle passive stiffness, relative to that of the ...

Control of calcium binding to and dissociation from cardiac troponin C (TnC) is essential to healthy cardiac muscle contraction/relaxation. There are numerous ...

Heart failure and cardiac arrhythmias are the leading causes of mortality and morbidity worldwide. However, the mechanism of pathogenesis and myocardial malfunction in the diseased heart remains to be ...

Muscles show a surprisingly large variety of functions when they mechanically respond to different environmental requests. However, the in vivo workloop studies distinguish well only four patterns of ...

Permeabilized murine cardiomyocytes from the remaining anterior and a remote non-infarcted inferior LV area were compared with those of non-infarcted age-matched controls. Myofilament phosphorylation, ...