† Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, United States ‡ Department of Chemistry & Biochemistry, Ohio State University, Columbus, Ohio 43210, ...

Coexistence of >1 cTnT variant results in a temporally split myofilament response to calcium impairing contractility. Analysis of healthy human hearts showed an association between rs1786814 GG ...

Using invasive pressure-volume loops, takotsubo syndrome (TTS) is associated with impaired cardiac contractility and a shortened systolic interval (with increased LV diastolic volume compensating for ...

Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, ...

Human heart failure is defined as the inability of the cardiac pump function to meet peripheral demands. Heart failure afflicts ∼6 million patients in the US and is associated with 1 in 9 deaths ...

To produce and validate myofilament-restricted Ca 2+ imaging probes in an adenoviral transduction adult cardiomyocyte model using drugs that alter myofilament function (MYK-461, omecamtiv mecarbil, ...

We are grateful to H. Lum and L. Carrier for providing Ad-PKI and the antibody against cMy-BPC, respectively. We are grateful to Aurore Germain, Florence Lefebvre, Guillermo Salazar, Patrice Bideaux, ...

Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited ...