The disruption of axons—the thread-like part of nerve cells that transmits electrical signals—is associated with Alzheimer's disease. One way axonal function may be hindered is through damage to the ...

While peripheral neuropathies have conventionally been classified into demyelinating or axonal, recent studies have proposed a novel concept, namely a ‘nodopathy’, whereby microstructural changes ...

The physiological significance of the node of Ranvier is now well known. The histological delineation of its length, however, still remains uncertain. Should it be identified as the gap between the ...

This unique insight into microglia-axon communication offers promising therapeutic targets for effective treatment strategies,” he said. The team demonstrated that microglia establish direct contact ...

Nodes of Ranvier Function The myelin sheath exists in sections called internodes. Between each internode are small spaces known as nodes of Ranvier. These nodes contain positive sodium ions, which ...

AUTHORS: Jiaxuan Wang KEYWORDS: Cryo-ET, Ion Channels Localization, The Nodes of Ranvier JOURNAL NAME: Journal of Biosciences and Medicines, Vol.8 No.2, February 7, 2020 ABSTRACT: The localization of ...

There are small gaps in the myelin coating, called nodes of Ranvier. The action potential jumps from gap to gap, allowing the signal to move much quicker.

During the transmission of electrical signals, the signal jumps from one Node or Ranvier to the next, allowing a myelin-containing fiber to transmit a signal 100 times faster than without myelin.