Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual ...

For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

Children who inherit genetic mutations from parents with early-onset Alzheimer’s typically show signs of dementia at the same ...

A groundbreaking study reveals how a rare combination of genetics, proteomics, and environmental factors may hold the key to ...

It is the memory-robbing disease that people fear the most as they age - and it is even more tragic when it strikes early. One of those affected is actress Pauline Quirke.

TASTPM is a double transgenic mouse model of Alzheimer’s disease carrying two mutations associated with early onset disease: the Swedish mutation in APP and the M146V mutation in PSEN1. The double ...

This animal is a cross between a PSEN1 knock-in line and an APP over-expressing line. The PS1 knock-in line was generated by introducing two point mutations in the wild-type mouse PSEN1, corresponding ...

The research, published today in eLife, is described by editors as a fundamental study providing insights into how mutations in the presenilin-1 (PSEN1) gene affect processing of the amyloid precursor ...

We recently reported evidence that FAD mutations in APP and PSEN1 cause deficiencies in early steps in processive proteolysis of APP substrate C99 and that this results from stalled γ-secretase enzyme ...