Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual ...

Children who inherit genetic mutations from parents with early-onset Alzheimer’s typically show signs of dementia at the same age their parents did.

For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

TASTPM is a double transgenic mouse model of Alzheimer’s disease carrying two mutations associated with early onset disease: the Swedish mutation in APP and the M146V mutation in PSEN1. The double ...

This animal is a cross between a PSEN1 knock-in line and an APP over-expressing line. The PS1 knock-in line was generated by introducing two point mutations in the wild-type mouse PSEN1, corresponding ...

Edited by Anne C. Hart, Brown University, Providence, RI; received August 29, 2024; accepted December 19, 2024 by Editorial Board Member Yishi Jin ...

We recently reported evidence that FAD mutations in APP and PSEN1 cause deficiencies in early steps in processive proteolysis of APP substrate C99 and that this results from stalled γ-secretase enzyme ...

Arafi et al. present results of studies designed to better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP). This ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. For several decades, researchers studying Alzheimer's disease have been working to ...