Objective Mutations in presenilin genes are the major cause of Alzheimer’s disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins ...

APP, PSEN1, or PSEN2 (Note that the apolipoprotein E E4 allele was not considered specific enough to meet criteria.) Step 4: Evaluate the "Biomarker probability of AD etiology" ...

APP, PSEN1, or PSEN2 (Note that the apolipoprotein E E4 allele was not considered specific enough to meet criteria.) Step 4: Evaluate the "Biomarker probability of AD etiology" Evaluate for atrophy of ...

These impairments were reversed upon PSEN2 re-expression, underscoring a specific implication for PSEN2 in the maintenance of mitochondrial morphology and homeostasis. However, and surprisingly, none ...

PSEN2 mutations have been found in cases of Parkinson's disease, bvFTD, semantic variant PPA, DLB, and nfvPPA. APP pathogenic variants or duplication of the gene have been associated with Parkinson's ...

Formation of amyloid fibrils by Aβ42 protein is a pathological hallmark of Alzheimer’s disease. Aβ42 fibrillization is a nucleation-dependent polymerization process, in which nucleation is the ...