Two oral presentations to highlight the safety, immunogenicity, and future development of AV-1959R for primary and secondary prevention of Alzheimer's disease ...

Andrew E. Budson, MD; Paul R. Solomon, PhD Disclosures Neurologist. 2012;18 (6):356-363.

However, APP gene linkage and mutations account for only a very small portion of FADs. [2, 3, 4] Another two closely related genes, the presenilins (PSEN1 and PSEN2), located on chromosomes 14q24 ...

PSEN2 mutations have been found in cases of Parkinson's disease, bvFTD, semantic variant PPA, DLB, and nfvPPA. APP pathogenic variants or duplication of the gene have been associated with Parkinson's ...

Genetic studies have provided important insights into the pathogenesis of Alzheimer´s disease (AD). In the early 1990s, the identification of mutations in the amyloid precursor protein (APP), ...