Two oral presentations to highlight the safety, immunogenicity, and future development of AV-1959R for primary and secondary prevention of Alzheimer's disease ...

Objective Mutations in presenilin genes are the major cause of Alzheimer’s disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins ...

By comparing all three genes—PSEN1, PSEN2, and APP—the study provided a unified model of familial Alzheimer’s disease. All three show a linear relationship between molecular changes and symptom onset, ...

The results also extended to mutations in PSEN2 and the APP gene, though with more variation. Even within the same family, people carrying the same PSEN2 mutation showed very different ages of onset.

Some clinical trials for treatments that nip Alzheimer’s disease in the bud rely on recruiting carriers of autosomal-dominant mutations who will develop Alzheimer’s disease in a predictable fashion.

In an exceptionally rare case, a patient with a high genetic risk of developing Alzheimer's appears to have avoided his probable fate for decades, according to new research. The man's situation is ...

PSEN2 mutations are associated with an accumulation of the protein amyloid-beta in the brain, which is currently considered a hallmark of Alzheimer’s disease, as well as an increased risk for ...

News Health Alzheimer's disease 'Doctors think I'm resistant to Alzheimer's in my 70s – findings could change world' A man in Oklahoma could be the missing piece scientists were looking for on ...

The family has been under scientific scrutiny for years, as their genetic mutation is linked to a rare form of Alzheimer's associated with a gene called PSEN2.

Despite carrying a dominant Presenilin 2 (PSEN2) p.Asn141Ile mutation, a known genetic link to Alzheimer's disease (AD), the participant displayed no AD symptoms even 18 years beyond the expected ...

Fig. 1–suppl. 1: Expression of zebrafish orthologues of early-onset Alzheimer’s risk genes from single-cell RNA-seq data. Expression of appa (a); appb (b); psen1 (c); psen2 (d) in brain cells of the ...

PSEN1 and PSEN2 are equally capable of unleashing Aβ peptides, but they do so within different cellular haunts. While PSEN1 prefers to bask on the cell surface and sometimes ventures into the early ...