Muscle stiffness responds well to drugs that reduce the associated hyperexcitability of the sarcolemma by interfering with sodium channels located on it. These drugs theoretically reduce ...

15 The skeletal muscle tissue is composed of fiber‐shaped myocytes. The muscle fibers are composed of sarcolemma, sarcoplasm, and cell nuclei. Muscle contraction strength is directly related to the ...

Rarely, there are aggregates of mitochondria with ragged-red fibres seen inside the sarcolemma. Forearm exercise testing and neurophysiology is non-diagnostic.17 Definitive diagnosis is made on ...

The clinical utility of the cancer chemotherapeutic agent doxorubicin (DOX) is limited by its cardiotoxicity. Doxorubicinol (DOXol), the major biometabolite of DOX, preferentially accumulates in ...

Abstract and Introduction Rationale for i.v. Antihypertensive Selection Clinical Pharmacology of i.v. Antihypertensives References There are potential concerns with the use of sodium nitroprusside ...

1 Department of Health, Human Function, and Rehabilitation Sciences, George Washington University, Washington, DC, USA 2 Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, ...

Duchenne muscular dystrophy (DMD) is caused by an out-of-frame mutation in the DMD gene that results in the absence of a functional dystrophin protein, leading to a devastating progressive lethal ...

Culture of L6 Cells, Development of Insulin-Resistant Cells, and Glucose Uptake Assays L6 cells are provided by Professor Pingsheng Liu (Institute of Biophysics, the Chinese Academy of Science). L6 ...

Institute of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK Correspondence to: Dr Anne Lampe Institute of Human Genetics, University of Newcastle upon Tyne, International ...