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SGT-501 is a novel gene therapy for rare, life-threatening, genetic arrhythmogenic disease with no approved therapies - - SGT-501 has received Orphan Drug Designation and Rare Pediatric Disease Design ...

Calcium-uptake and ATPase studies carried out on fragmented sarcoplasmic reticulum from muscle of patients with Duchenne dystrophy showed low initial and total calcium uptake, low ATPase activity a ...

The Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 pipeline targets constitutes close to nine molecules. Out of which, approximately nine molecules are developed by companies and the remaining by ...

A new method for assessing sarcoplasmic reticulum (SR) Ca2+-leak in atrial myocytes using confocal line-scan Ca2+ imaging is proposed. This approach offers a simpler and more ...

Sarcoplasmic reticulum/endoplasmic reticulum ATPase 2a (SERCA2a) is a calcium pump for calcium ion recycling in the sarcoplasmic reticulum in cardiomyocytes.

Sarcoplasmic reticulum (SR) Ca release refractoriness is impaired in K180R cardiomyocytes. To measure the refractoriness of SR Ca release, isolated cardiomyocytes were loaded with the Ca indicator ...

Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban ...

In summary, we have developed a robust and efficient method for imaging SR Ca 2+ with high sensitivity and spatiotemporal resolution. We anticipate that it will be broadly applicable to a large panel ...

Muscle contraction is known to be regulated by calcium. An action potential generated by a motor neuron propagates on the muscle cell surface, activates voltage-gated calcium channels and allows ...