These T-tubules, or transverse tubules, are responsible for cardiac muscle cell contraction. T-tubule alterations are common features of heart failure, ...

JP2 protein is critical to the normal organization of an important component of heart muscle membrane network called Transverse-tubules or T-tubules.

Sildenafil prevents and reverses transverse-tubule remodeling and Ca 2+ handling dysfunction in right ventricle failure induced by pulmonary artery hypertension. Hypertension 2012; 59: 355–62.

These structures are known as transverse tubules and are responsible for the contraction and relaxation of muscles. Abnormalities of the tubules lead to the muscle weakness characteristic of CNM.

M. Ibrahim et al. Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2 -induced Ca2 release in a rodent model of heart failure. European Journal of Heart Failure ...

The mechanisms that determine the release of Ca from the store has been a central component of my work over several years. We know that the surface membrane Ca channels are concentrated in transverse ...