The purpose of this study was to test whether sildenafil suppressed transverse-tubule (T-tubule) remodeling in left ventricular (LV) failure and thereby providing the therapeutic benefits.

Location, location, location JP2 protein is critical to the normal organization of an important component of heart muscle membrane network called Transverse-tubules or T-tubules.

Download your complete guide on renal proximal tubule cells models and their applications.

Aside from disrupting proteostasis, loss-of-function mutations in BAG5 were also found to “disturb transverse tubule morphology and perturb calcium handling in mouse cardiomyocytes” by ...