Amyloid precursor protein, which generates amyloid-β when broken down, has long been associated with Alzheimer’s disease. But its normal function in the brain has remained relatively mysterious. Over ...

Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed ...

Increasing focus is now being placed on the production of Aβ—a process called proteolysis, during which a precursor protein ...

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain. A protein from Helicobacter pylori inhibits amyloid formation in both ...

Amyloid Precursor Protein (APP) is a type-I transmembrane protein with enriched expression in neuronal tissues. APP undergoes sequential proteolytic processing through two distinct pathways: 1) the ...

Explore the link between α2,6-sialyltransferase-I and Alzheimer's disease progression. Understand the new findings on ...

"Amyloid precursor protein may just be one of the many accomplices partially contributing to cholesterol deficiency. Strangely, the heart and brain seem to meet again in the fight against bad ...

For this, they examined the expression of the genes BACE1 and APP, which code for beta-secretase component 1 and amyloid precursor protein, respectively, and the MBP gene, which codes for myelin ...

All the latest science news on amyloid precursor protein from Phys.org. Find the latest news, advancements, and breakthroughs.

Aducanumab, a new antibody has been shown to trigger a meaningful reduction of harmful beta-amyloid plaques in patients with early-stage Alzheimer's disease. These protein deposits in the brain ...