Amyloid precursor protein, which generates amyloid-β when broken down, has long been associated with Alzheimer’s disease. But its normal function in the brain has remained relatively mysterious. Over ...

Increasing focus is now being placed on the production of Aβ—a process called proteolysis, during which a precursor protein ...

Explore the link between α2,6-sialyltransferase-I and Alzheimer's disease progression. Understand the new findings on ...

Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed ...

This iron buildup is harmful because it triggers oxidative stress, a process that damages cells by producing toxic molecules.

For this, they examined the expression of the genes BACE1 and APP, which code for beta-secretase component 1 and amyloid precursor protein, respectively, and the MBP gene, which codes for myelin ...

When you look at the brain of someone with Alzheimer’s under a microscope, it requires two proteins — beta-amyloid and tau protein, which is thought to occur after amyloid, says Dr. Younes.

Here, Tian et al. report that lactylation curbs Aβ production and plaque formation via lactate modification of specific lysines on amyloid precursor protein. This alters APP intracellular transport ...

A key protein in AD pathogenesis is the enzyme β-secretase (BACE1), which cleaves amyloid precursor protein (APP) to generate neurotoxic amyloid beta (Aβ42), potentially leading to neuronal loss.

Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor proteins clump together to create amyloid-beta plaques, which eventually disrupt how brain cells work. Tau: In the healthy brain ...

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