WEST CHESTER, PA — Pathways Neuro Pharma Inc. has announced a significant pivot in its development pipeline, prioritizing ...

Northwestern Medicine investigators have uncovered new insights into how metabolic dysfunction contributes to Parkinson's ...

Published in the journal PLOS Biology, the study shows that this metabolite is responsible for the formation of Lewy bodies and the death of dopaminergic neurons in the brain—the two major ...

Lowering oxysterol, in both animal models and human stem cells, freed the trapped ABCA1 and restored the pathway to its healthy state. Lowering oxysterol could be a new way to prevent or treat ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of ...

In the mouse olfactory bulb, closely related subclasses of dopaminergic interneuron differ markedly in their polarity, with one subtype lacking an axon entirely. These axon-bearing and anaxonic ...

A recent Brazilian study published in Nature Cardiovascular Research has highlighted promising pathways for preventing and treating atrial fibrillation, a condition that significantly raises the ...

We could, for example, investigate physiological specificity by analyzing the genetic polymorphisms of the dopaminergic pathway. The studies involving human participants were reviewed and approved by ...

By comparing control and Ox1R ΔDAT mouse data, we first identified behaviors modulated by orexin via dopaminergic neurons. In a second step, we used PET imaging to define and map neuronal pathways ...