Deleting a gene called PTEN in certain brain cells disrupts the brain’s fear circuitry and triggers anxiety-like behavior in ...

Interneurons work a bit like the brain's traffic controllers where they regulate the firing of other brain cells, acting like ...

Researchers have uncovered how losing the autism-linked gene PTEN in a specific set of inhibitory neurons reshapes brain circuits tied to fear and anxiety.

After numerous face injuries, five facial reconstruction surgeries and three wrecked cars due to epilepsy, a University of Arkansas for Medical Sciences patient has received the first transplantation ...

Research from the Max Planck Florida Institute reveals that loss of the PTEN gene in inhibitory neurons within the amygdala ...

Adolescent diets high in fat and sugar disrupt the development of the prefrontal cortex and hippocampus, impacting cognition, ...

Conditional knockout of PTEN from SOM neurons leads to elevated fear and anxiety phenotype. Credit: Frontiers in Cellular Neuroscience (2025). DOI: 10.3389/fncel.2025.1597131 ...

A study in mice has unpicked the neuronal circuitry responsible for pain suppression in threatening situations, pointing towards better pain relief treatments.

Next the team sought to determine the cell types within the vlPAG that mediated this effect, focusing on the most abundant group—somatostatin (SST)-expressing interneurons.